NFL Picks: Parlays, Best Bets, Player Props, and Expert Predictions Against the Spread.

Indianapolis Colts vs Arizona Cardinals Prediction, 12/25/2021 NFL Picks, Best Bets & Odds Week 16
by Josh Schonwald - 12/21/2021

The Arizona Cardinals (10-4) host the Indianapolis Colts (8-6) at State Farm Stadium on Saturday. Indianapolis opens this matchup as 1.5-point underdogs. The over/under is set at 49.5. This matchup report includes football betting lines and our pick of the day for this game.

Denver Broncos vs Las Vegas Raiders Prediction, 12/26/2021 NFL Picks, Best Bets & Odds Week 16
by Guy Bruhn - 12/21/2021

The Denver Broncos (7-7) are headed to Allegiant Stadium on Sunday where they will try to beat the Las Vegas Raiders (7-7). Denver opens this contest as 1-point dogs from oddsmakers. The total comes in at 42.5. This matchup report includes betting lines and our NFL pick of the day for this game.

Chicago Bears vs Seattle Seahawks Prediction, 12/26/2021 NFL Picks, Best Bets & Odds Week 16
by Josh Schonwald - 12/21/2021

The Seattle Seahawks (5-9) are hosting the Chicago Bears (4-10) at Lumen Field on Sunday. Chicago is 7-point dogs. The over/under is set at 44. This matchup report includes odds, NFL betting predictions and a free pick against the spread.

Cleveland Browns vs Green Bay Packers Prediction, 12/25/2021 NFL Picks, Best Bets & Odds Week 16
by Guy Bruhn - 12/21/2021

The Cleveland Browns (7-7) are traveling to Lambeau Field on Saturday where they will attempt to defeat the Green Bay Packers (11-3). Green Bay opens as 8-point favorites. The total comes in at 45.5. This report includes betting predictions and our expert NFL picks for todays game.

Jacksonville Jaguars vs New York Jets Prediction, 12/26/2021 NFL Picks, Best Bets & Odds Week 16
by Tony Sink - 12/21/2021

The Jacksonville Jaguars (2-12) are hitting the road to MetLife Stadium on Sunday where they will try to defeat the New York Jets (3-11). Jacksonville is 2.5-point dogs from oddsmakers. The betting total comes in at 41.5. This game report has an NFL football pick, betting odds, and predictions for tonights key matchup.

Los Angeles Rams vs Minnesota Vikings Prediction, 12/26/2021 NFL Picks, Best Bets & Odds Week 16
by Guy Bruhn - 12/21/2021

The Los Angeles Rams (10-4) are on their way to U.S. Bank Stadium on Sunday where they will take on the Minnesota Vikings (6-7). Los Angeles opens as 3-point favorites from oddsmakers. The over/under comes in at 49.5. This matchup report has your NFL football pick of the day as well as NFL football odds for the game.

New York Giants vs Philadelphia Eagles Prediction, 12/26/2021 NFL Picks, Best Bets & Odds Week 16
by Guy Bruhn - 12/21/2021

The New York Giants (4-10) are en route to Lincoln Financial Field on Sunday where they will attempt to beat the Philadelphia Eagles (7-7). New York opens this matchup as 10-point dogs from Vegas oddsmakers. The total has been set at 42. This matchup report includes Vegas odds and a free NFL pick for tonight.

Tampa Bay Buccaneers vs Carolina Panthers Prediction, 12/26/2021 NFL Picks, Best Bets & Odds Week 16
by Guy Bruhn - 12/21/2021

Bank of America Stadium is the site where the Carolina Panthers (5-9) will take on the Tampa Bay Buccaneers (10-4) on Sunday. Carolina opens this matchup as 11.5-point dogs. The over/under is set at 48.5. This matchup report includes Vegas odds and a free NFL prediction for tonight.

Seattle Seahawks vs Los Angeles Rams Prediction, 12/21/2021 NFL Picks, Best Bets & Odds Week 15
by Guy Bruhn - 12/14/2021

SoFi Stadium is the location where the Los Angeles Rams (8-4) will meet the Seattle Seahawks (5-8) on Tuesday. Seattle opens this contest as 7-point dogs. The total is 47. This matchup report includes betting lines and our NFL pick of the day for this game.

Arizona Cardinals vs Detroit Lions Prediction, 12/19/2021 NFL Picks, Best Bets & Odds Week 15
by Guy Bruhn - 12/14/2021

Ford Field is the site where the Detroit Lions (1-11-1) will attempt to defeat the Arizona Cardinals (10-2) on Sunday. Arizona is 14-point favorites. The over/under is set at 41.5. This matchup report has your NFL football pick of the day as well as NFL football odds for the game.

New York Jets vs Miami Dolphins Prediction, 12/19/2021 NFL Picks, Best Bets & Odds Week 15
by Guy Bruhn - 12/13/2021

Hard Rock Stadium is where the Miami Dolphins (6-7) will attempt to beat the New York Jets (3-10) on Sunday. Miami opens this game as 8.5-point favorites. The over/under is set at 45.5. This matchup report includes Vegas odds and a free NFL prediction for tonight.

Tennessee Titans vs Pittsburgh Steelers Prediction, 12/19/2021 NFL Picks, Best Bets & Odds Week 15
by Guy Bruhn - 12/13/2021

The Tennessee Titans (9-4) are en route to Heinz Field on Sunday where they will try to beat the Pittsburgh Steelers (6-6-1). Tennessee opens this contest as 2.5-point favorites. The total is 40.5. This matchup report includes Vegas odds and a free NFL pick for tonight.

Cincinnati Bengals vs Denver Broncos Prediction, 12/19/2021 NFL Picks, Best Bets & Odds Week 15
by Josh Schonwald - 12/13/2021

Empower Field at Mile High is the site where the Denver Broncos (7-6) will go up against the Cincinnati Bengals (7-6) on Sunday. Denver opens this contest as 1.5-point favorites from oddsmakers. The betting total is set at 46. This matchup report includes odds, NFL betting predictions and a free pick against the spread.

Houston Texans vs Jacksonville Jaguars Prediction, 12/19/2021 NFL Picks, Best Bets & Odds Week 15
by Josh Schonwald - 12/13/2021

The Houston Texans (2-11) are on their way to TIAA Bank Field on Sunday where they will take on the Jacksonville Jaguars (2-11). Houston opens as 3-point underdogs. The total is set at 45. This report has odds and your NFL football predictions for todays game against the spread.

Dallas Cowboys vs New York Giants Prediction, 12/19/2021 NFL Picks, Best Bets & Odds Week 15
by Tony Sink - 12/13/2021

The Dallas Cowboys (9-4) are hitting the road to MetLife Stadium on Sunday where they will try to defeat the New York Giants (4-9). Dallas is 11-point favorites. The over/under has been set at 45. This game report has an NFL football pick, betting odds, and predictions for tonights key matchup.

New England Patriots vs Indianapolis Colts Prediction, 12/18/2021 NFL Picks, Best Bets & Odds Week 15
by Parlays Pundit - 12/13/2021

Lucas Oil Stadium is the location where the Indianapolis Colts (7-6) will attempt to defeat the New England Patriots (9-4) on Saturday. New England is 2-point underdogs. The total is set at 42.5. We have included an expert NFL pick and parlay for todays game against the spread.