New York Giants vs San Francisco 49ers Prediction, 9/21/2023 NFL Picks, Best Bets & Odds Week 3

Game: New York Giants vs San Francisco 49ers

Date: Thursday, September 21, 2023

Location: Levi's Stadium in Santa Clara, CA

TV: PRIME VIDEO

Odds/Point Spread: 49ers (-9.5)

Total/Over-Under: 43.5

Levi's Stadium is the site where the San Francisco 49ers (2-0) will go up against the New York Giants (1-1) on Thursday. San Francisco opens this contest as 9.5-point favorites from oddsmakers. The total has been set at 43.5.

The New York Giants head into this matchup 1-1 for this season. When they last stepped on the football field, the Giants faced the Cardinals and walked away with a win by a score of 31-28. Daniel Jones connected on 26/37 with 321 yds passing and 2 touchdowns. He had a quarterback rate of 103.5 and ended the contest with 1 interception. Jalin Hyatt had an average of 44.5 yards per catch by totaling 89 yards on 2 catches. Saquon Barkley led the offense in rushing for the Giants with 17 carries for 63 yds (3.7 yds per attempt). In all, they ran 67 plays for 439 yds. The New York Giants ran the football 27 times and had 127 yds, earning them an average of 4.7 yards per attempt. In the running game, the Giants conceded 151 yds on 29 tries, which is 5.2 yds per run surrendered. New York allowed 21 completions on 31 tries for a total of 228 yds, and a completion percentage of 67.7%.

The Giants have tallied 610 total yards this season. New York has recorded 20 first downs as an offense, and they have committed 15 infractions for 147 yds. When it comes to notching touchdowns, New York has totaled 2 touchdowns through the air and 2 touchdowns on the ground. They have surrendered the ball 4 different times (3 interceptions and 1 fumble lost). As a team they're maintaining an average of 117.5 yards on the ground which ranks them 13th in the NFL. Regarding scoring points, the New York Giants hold an average of 15.5 points per contest.

When talking about yards through the air, the Giants have conceded 371 yards which has them sitting in 9th in the league. They have given up 185.5 yards per contest via the pass and allowed a completion percentage of 60.7%. Over the course of this season, they are surrendering 322.0 yards/outing which ranks them 15th in football. They are giving up an average of 4.6 yards per rush and 136.5 rushing yards per game for the year. Over the course of this year, they have allowed 273 running yards through 2 games. The Giants rank 32nd in the league when it comes to team defense, allowing 34.0 PPG.

Get all of our Free NFL Picks

The 49ers head into this matchup 2-0 for this season. When they last stepped on the football field, the 49ers got the victory with a final of 30-23 when they faced the Rams. Brock Purdy ended the contest with 206 yds on 17/25 passing while his quarterback rating was 93.1. He didn't throw any picks and his average yards per pass attempt was 8.2 yds. Christian McCaffrey carried the rock 20 times for 116 yards, ending the contest with 5.8 yds per carry for San Francisco. Deebo Samuel was one of the featured targets for the 49ers, grabbing 6 passes for 63 yds (10.5 yds per catch). San Francisco rushed the ball for 5.7 yards per attempt, finishing with 159 yds on 28 attempts. The 49ers finished the contest with a total of 365 yds while they ran 54 plays (6.8 yds per play). The 49ers pass defense conceded a completion rate of 61.8%, relinquishing 297 yds on 34 out of 55 passing. San Francisco conceded 22 running attempts for 89 yards (4.0 yds per rush).

The San Francisco 49ers are averaging 378.0 yards per outing which is good for 7th in the NFL. They average 173.5 run yards per game and have toted the ball for 347 yards for this season. They have given away 0 interceptions while letting opponents recover 1 fumble and they have been able to earn 24 first downs. The San Francisco offense has accrued 142 yds of penalties on 17 violations, which is 3rd in football in terms of making mistakes. During this campaign thus far, the 49ers have thrown for a total of 409 passing yards in addition to holding an average of 204.5 throwing yards per outing, giving them a rank of 16th in the league. Regarding putting points on the board, the 49ers rank 3rd in the NFL maintaining an average of 30.0 PPG.

The 49ers are conceding 15.0 points per game, which has them sitting 4th of all teams in the league. They have yielded 2 touchdowns through the air and 247.5 yards/game, which puts them in 23rd in the NFL. San Francisco has given up a total of 130 yards via the ground game (65.0 yards/game) as well as 1 touchdown via the rush for the season. The 49ers defense has taken part in 139 plays, which is 24th in the league. They have 4 turnovers (0 fumbles recovered and 4 interceptions) on the season. Over the course of the season, they have conceded 30 points in total.

Who will win tonight's Giants/49ers NFL game against the spread?

Tony's Pick: Take the Giants +9.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here