Arizona Cardinals vs San Francisco 49ers Prediction, 10/1/2023 NFL Picks, Best Bets & Odds Week 4

Game: Arizona Cardinals vs San Francisco 49ers

Date: Sunday, October 1, 2023

Location: Levi's Stadium in Santa Clara, CA

TV: FOX

Odds/Point Spread: 49ers (-14.5)

Total/Over-Under: 41

The Arizona Cardinals (1-2) are hitting the road to Levi's Stadium on Sunday where they will compete against the San Francisco 49ers (3-0). Arizona opens this matchup as 14.5-point dogs from oddsmakers. The betting total is set at 41.

The Arizona Cardinals step onto the field holding a record of 1-2 this season. In their last game, the Cardinals faced the Cowboys and earned the victory with a final of 28-16. Joshua Dobbs finished 17/21 with 189 yds through the air and 1 TD. He had a quarterback rating of 120 and ended the contest with no interceptions. James Conner was the best rusher for the Cardinals with 14 carries for 98 yards (7.0 yards per carry). Michael Wilson held an average of 43.0 yds per reception by totaling 86 yards on 2 catches. The Arizona Cardinals ended up running the ball 30 times and recorded 222 yards, which is an average of 7.4 yds per carry. For the game, they had 53 plays which gave them a total of 400 yds. Arizona allowed 25 completions on 40 attempts for a total of 231 yds, and a completion percentage of 62.5%. In the running game, the Cardinals conceded 185 yards on 33 attempts, which calculates to 5.6 yards per run surrendered.

When it comes to putting points on the board, the Arizona Cardinals are averaging 24.0 points per outing. As a team they're averaging 156.3 yards on the ground which is 6th in the National Football League. The Cardinals have earned 989 yards in total for the year. Arizona has 28 1st downs offensively, and they have committed 25 penalties for 248 yds. They have surrendered the football 2 times (2 fumbles lost). In terms of getting in the endzone, Arizona has compiled 2 touchdowns through the air and 4 rushing touchdowns.

In terms of yards through the air, the Cardinals have given up 699 yards which ranks them 21st in the league. They have given up 233.0 yards per contest via the pass in addition to giving up a completion percentage of 64.8%. Over the course of this season, they are conceding 367.7 yards/outing putting them at 26th in the league. They are allowing teams to run for an average of 4.6 yards per rush and 134.7 yards on the ground per contest for the season. For the season, they have given up 404 rushing yards through 3 games. The Cardinals are sitting in 16th in the NFL concerning team defense, allowing 22.3 points per game.

Get all of our NFL Expert Picks

The 49ers head into this game 3-0 for this year. In their last contest, the 49ers got the victory with a final of 30-12 against the Giants. Christian McCaffrey ran the football 18 times for 85 yds, finishing the game with 4.7 yards per carry for San Francisco. Deebo Samuel was a featured target for the 49ers, grabbing 6 balls for 129 yards (21.5 yards per catch). Brock Purdy (2 TDs) ended the game with 310 yds on 25/37 passing while his quarterback rating was 111.3. He didn't throw any picks and his average yds per pass attempt was 8.4 yards. San Francisco conceded 11 run attempts for 29 yds (2.6 yards per carry). The 49ers passing defense conceded a completion rate of 66.7%, surrendering 121 yds on 22 for 33 passing. The 49ers finished the game with a total of 441 yds and they ran 78 plays (5.7 yds per play). San Francisco rushed the football for 3.6 yds per carry, finishing with 141 yds on 39 attempts.

When looking at putting points on the board, the 49ers rank 3rd in the league holding an average of 30.0 points per outing. For the year so far, the 49ers currently sit at 709 yards through the air in addition to an average of 236.3 passing yards per contest, which has them ranked 10th in the league. They maintain an average of 162.7 rushing yards per game and have toted the ball for 488 yards overall. The San Francisco 49ers average 399.0 yards per outing ranking them 4th in the league. The San Francisco offense has 213 penalty yards on 23 infractions, which ranks them 7th in the league in terms of helping out the opposition. They have given away 0 picks while allowing opponents to recover 1 fumble and they have been able to obtain 37 first downs.

They have allowed 2 touchdowns through the air and 205.3 yards per contest, which has them ranked 14th in the league. San Francisco has yielded a total of 159 yards on the ground (53.0 yards per game) and 2 touchdowns via the rush this season. Overall, they have conceded 42 total points. Their defense has 5 takeaways (0 fumbles recovered and 5 picks) this year. The 49ers defense has participated in 185 plays, ranking them 10th in the league. The 49ers are surrendering 14.0 points per contest, which puts them in 5th of all teams in the NFL.

Who will win tonight's Cardinals/49ers NFL game against the spread?

Guy's Pick: Take the 49ers -14.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here