San Francisco 49ers vs Arizona Cardinals Prediction, 10/10/2021 NFL Pick, Tips and Odds, Week 5

Game: San Francisco 49ers vs Arizona Cardinals

Date: Sunday, October 10, 2021

Location: State Farm Stadium in Glendale, AZ

TV: FOX

Odds/Point Spread: Cardinals (-2.5)

Total/Over-Under: 52.5

The Arizona Cardinals (4-0) welcome the San Francisco 49ers (2-2) at State Farm Stadium on Sunday. Arizona opens this contest as 2.5-point favorites from Vegas oddsmakers. The over/under is 52.5.

The San Francisco 49ers step onto the field holding a record of 2-2 this year. In their last contest, the 49ers faced the Seahawks and ended up losing by a score of 28-21. Jimmy Garoppolo went 14/23 with 165 yards passing and 1 TD. He had a quarterback rating of 79.1 and ended the contest with 1 interception. Trey Sermon was the leader on the ground for the 49ers with 19 attempts for 89 yds (4.7 yards per attempt). Deebo Samuel averaged 19.5 yds per catch by earning 156 yds on 8 catches. The San Francisco 49ers ended up running the ball 29 different times and recorded 143 yds, which is an average of 4.9 yards per carry. For the game, they ran 72 plays which converted into 457 yards. San Francisco allowed 16 completions on 23 attempts for a total of 129 yds, and a completion percentage of 69.6%. On the ground, the 49ers gave up 105 yards on 28 tries, which is 3.8 yds per run surrendered.

The 49ers have earned 1,503 total yards this season. San Francisco has 51 first downs as a team, and they have committed 25 infractions for 318 yds. In terms of getting in the endzone, San Francisco has amassed 8 passing touchdowns and 5 touchdowns on the ground. They have turned the football over 6 times (2 picks and 4 fumbles). As a team they're holding an average of 114.5 yards via the ground game which has them sitting 12th in the league. Regarding putting points on the board, the San Francisco 49ers are sitting at 26.8 points per game.

The 49ers are sitting in 22nd in the NFL when it comes to the opposition scoring, giving up 25.5 points per game. They are allowing 4.5 yards per rushing attempt and 118.0 rushing yards per game for the season. In total, they have allowed 472 running yards through 4 contests. When talking about passing yards, the 49ers have allowed 873 yards which has them ranked 10th in the National Football League. They are conceding 218.3 yards per contest via the pass in addition to giving up a completion percentage of 65.0%. Overall, they have allowed 336.3 yards/contest which puts them 10th in the NFL. They have allowed 7 touchdowns by air as well as 5 touchdowns on the ground.

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The Cardinals step onto the field holding a record of 4-0 for this season. In their last game, the Cardinals got the victory with a final of 37-20 against the Rams. Kyler Murray (2 TDs) ended the game with 268 yards on 24/32 passing while his quarterback rating was 120.3. He didn't throw any picks and his longest completion was 41 yds. A.J. Green was a featured target for the Cardinals, bringing in 5 passes for 67 yards (13.4 yds per catch). Chase Edmonds carried the rock 12 times for 120 yards, walking away from the game with 10.0 yards per attempt for Arizona. The Cardinals finished the game with a total of 465 yds on 75 plays (6.2 yards per play). Arizona rushed the ball for 5.4 yards per attempt, finishing with 216 yards on 40 attempts. Arizona gave up 23 run attempts for 121 yds (5.3 yds per rush). The Cardinals secondary conceded a completion percentage of 63.4%, relinquishing 280 yards on 26 for 41 through the air.

The Arizona Cardinals maintain an average of 440.5 yards per outing which is good for 1st in the NFL. They have an average of 136.5 run yards per game and have run for 546 yards in total. The Arizona offense has accrued 220 penalty yards on 27 infractions, which is 11th in the league in terms of hurting your team. They have thrown 4 picks while surrendering 0 fumbles and they have been able to earn 54 1st downs. Over the course of the season thus far, the Cardinals currently sit at 1,216 passing yards along with an average of 304.0 throwing yards per outing, which ranks 3rd out of all NFL teams. When discussing how much they score, the Cardinals are 1st in the league by tallying 35.0 points per contest.

The Cardinals are relinquishing 21.3 PPG, which has them sitting 9th in football. Arizona has yielded a total of 543 rushing yards (135.8 yards per contest) and 2 touchdowns via the rush this season. They have allowed the opposition 7 touchdowns through the air as well as 221.5 yards per game, which has them sitting 11th in the league. The Cardinals defense taken the field for 254 plays, which is 15th in the league. Over the course of the season, they have conceded 85 points in total. Their defense has compiled 9 takeaways (5 fumbles recovered and 4 picks) this season.

Who will win tonight's 49ers/Cardinals NFL game against the spread?

Tony's Pick: Take the 49ers +2.5

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