Sunday, October 5, 2014 at 4:25 PM on CBS

Levi's Stadium in Santa Clara

For Updated Odds on This Game Click Here

In a game that will feature two of the best running games in the NFL, the Kansas City Chiefs (2-2) will take on the San Francisco 49ers (2-2) on Sunday afternoon.

After losing their first two games, the Chiefs have now won two in a row after beating the New England Patriots 41-14 last Monday. Kansas City outgained the Patriots 443-290 in that game and their defense was able to force three turnovers.

The Chiefs have rushed for 145.3 yards per game through their first four games, which is fourth-best in the NFL right now. Outside linebacker Justin Houston has 15 tackles this season and five sacks, which is tied for tops in the NFL. Quarterback Alex Smith has completed 65.6 percent of his passes for 891 yards with seven touchdowns and three interceptions.

The 49ers were able to hold the Eagles to just 213 total yards on Sunday and ended up beating them 26-21. San Francisco forced two fumbles and picked off two passes in the win while their offense rushed for 218 yards.

San Francisco's defense has only given up 287.3 yards per game this season, which is second-best in the league. Wide receiver Michael Crabtree has 24 catches through four games with 230 yards and two touchdowns. Pro Bowl defensive end Justin Smith has eight tackles this season and leads the team with three sacks.

Kansas City Chiefs Betting Trends

Kansas City Chiefs are 3-1-0 Against the Spread

Kansas City Chiefs are 2-2-0 against the Over/Under

San Francisco 49ers Betting Trends

San Francisco 49ers are 2-2-0 Against the Spread

San Francisco 49ers are 1-3-0 against the Over/Under

Injuries to Watch

Kansas City Chiefs

09/29/14 RB De'Anthony Thomas Hamstring "?" Sunday vs. San Francisco
09/29/14 WR Donnie Avery Groin injured last game, "?" Sunday vs. San Francisco
09/29/14 S Eric Berry Ankle "?" Sunday vs. San Francisco
09/26/14 RB Joe McKnight Achilles out for season
09/25/14 LB Mike Catapano Illness IR
09/10/14 LB Derrick Johnson Achilles IR
09/10/14 DE Mike DeVito Achilles IR
09/04/14 OL Donald Stephenson Suspension expected to miss weeks 1-4 of regular season
09/04/14 LB Joe Mays Wrist out indefinitely
09/04/14 DB Sanders Commings Ankle IR
09/04/14 QB Tyler Bray Ankle IR

San Francisco 49ers

09/29/14 T Anthony Davis Knee "?" Sunday vs. Kansas City
09/29/14 TE Vernon Davis Back "?" Sunday vs. Kansas City
09/28/14 C Marcus Martin Knee "?" Sunday vs. Kansas City
09/28/14 CB Tramaine Brock Toe "?" Sunday vs. Kansas City
09/28/14 TE Vance McDonald Knee "?" Sunday vs. Kansas City
09/23/14 NT Glenn Dorsey Bicep IR
09/23/14 CB Kenneth Acker Undisclosed IR
09/04/14 LB Aldon Smith Suspension expected to miss weeks 1-10 of regular season
09/04/14 T Brandon Thomas Knee out indefinitely
09/04/14 RB Marcus Lattimore Knee out indefinitely
09/04/14 LB NaVorro Bowman Knee PUP
09/04/14 FB Trey Millard Knee out indefinitely
09/04/14 TE Garrett Celek Back PUP
09/04/14 DT Kaleb Ramsey Undisclosed PUP
09/04/14 CB Keith Reaser Knee out indefinitely
09/04/14 RB Kendall Hunter Knee IR

Josh's Pick: Take Kansas City

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