St. Louis Cardinals vs Cincinnati Reds Prediction, 4/28/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Cincinnati Reds

Date: Monday, April 28, 2025

Location: Great American Ball Park in Cincinnati, OH

TV: FanDuel Sports Network Ohio

Odds/Point Spread: St. Louis (+120) Cincinnati (-144)

The St. Louis Cardinals (10-15) are hitting the road to Great American Ball Park on Monday where they will attempt to defeat the Cincinnati Reds (12-13). The odds on this game have the Cardinals at +120 and the Reds are coming in at -144. The over/under has been set at 9. The men taking the mound are Andre Pallante and Nick Martinez.

As a squad, the St. Louis Cardinals are recording 4.8 runs per contest, which ranks them 7th in MLB. They have tallied 120 runs while having a team on-base percentage of .335. The Cardinals have hit 51 two-baggers as a unit and have hit 23 balls out of the park. They have tallied 114 runs batted in in addition to 232 base knocks over the course of the season, while their team batting average is at .264. St. Louis has a slugging % of .403 and have struck out 202 times, while drawing a walk on 88 occasions.

Get all of our Free MLB Picks

The Cardinals are sitting with a team ERA of 4.37 this year (23rd in MLB), and their staff has struck out 175 batters. Cardinals pitchers have given up 22 home runs and 118 runs in total (22nd in the league). They have walked 78 hitters and their FIP comes in at 3.85 as a squad over the course of the season. St. Louis has conceded 197 base hits (8.0 per 9 innings) in addition to 108 earned runs. They have accrued a K/BB ratio of 2.24 and their pitching staff has a team WHIP of 1.24.

The Cardinals have sent 83 relievers to the mound so far this year. The relievers have inherited 30 base runners this season with 50.0% of those players ended up crossing the plate. They have accumulated 5 saves so far this year and have not converted 6 out of their 11 save opportunities. The Cardinals relief pitchers have earned a save percentage of 45.5% and have stepped onto the mound in 25 save situations. The relievers have racked up 14 holds on the season (21st in baseball). Cardinals bullpen pitchers have stepped onto the hill with opponents on base 27 times in addition to having 37 appearances in high leverage situations.

The Cardinals have converted 72.1% of baseballs in play into outs out of their 2,004 innings, which has them ranked 7th in professional baseball. The St. Louis Cardinals have earned 668 putouts for the season, as well as 247 assists and 10 errors. Their fielding rate sits at .989 which puts them in 4th in professional baseball, and have accumulated 15 double plays.

Pallante has taken the ball for 323 innings and has accounted for 226 K's during his MLB career. Pallante (20-15 career mark) holds a FIP of 3.76 and he has gone up against 1,380 batters in the major leagues. His ERA is 3.81 (137 ER's allowed) and his WHIP is 1.395. He has conceded 323 base hits (9.0 hits per nine innings) and has 128 walks.

The Cincinnati Reds are sitting with an on-base percentage of .324 and a team batting average of .242 so far this year. They have struck out on 220 instances (10th in the league) and have accounted for 202 base hits. Cincinnati has accounted for 28 HRs for the season and 123 RBIs. The Reds have a team slugging percentage of .391 and they score 5.12 runs per game (4th in MLB). They have 39 doubles, while walking 93 times as well as earning 128 runs.

The Reds hold a team WHIP of 1.095 in addition to having a FIP of 4.16 as a team on the campaign. They have a ranking of 4th in MLB as a pitching staff in total hits allowed with 170. The Cincinnati pitching staff have given up 97 runs on the year and come in with a team ERA of 3.39 (83 earned runs yielded). Their strikeout to walk ratio sits at 8.10 (199 strikeouts against 71 bases on balls). They have allowed 32 homers and they give up 3.97 runs per 9 innings (7th in baseball).

Sitting with 31 save situations, the Reds have 19 holds and 4 blown saves. Cincinnati has called on bullpen pitchers to enter the contest in 11 save chances and they have walked away with 7 saves. Their relief pitchers have taken the field 23 times in high leverage situations in addition to 22 occasions with base runners. Cincinnati relievers hold an inherited score rate of 20.6% out of their 34 inherited runners. They are ranked 16th in MLB holding a save rate of 63.6%, and they have dispatched 82 bullpen pitchers to the hill on the season.

Out of their 1,983 innings on the field, the Reds hold a defensive efficiency of 75.1% (1st in MLB). The Cincinnati Reds have turned 8 double plays and own a fielding percentage of .982 (22nd in MLB). The Reds have accrued 172 assists, 15 errors and are sitting with 661 putouts for the year.

During his MLB career, Martinez has allowed 805 base knocks while he has earned 577 strikeouts in 800 frames. Martinez (37-48 win-loss record in his career) has a 4.14 earned run average while allowing 9.1 hits per 9 innings. He has given up 368 ER's while holding a WHIP of 1.326 and a FIP of 4.1. He has a strikeout to walk ratio of 2.25 and he has faced 3,419 opposing hitters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take St. Louis (+120)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here