St. Louis Cardinals vs Boston Red Sox Prediction, 4/6/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Boston Red Sox

Date: Sunday, April 6, 2025

Location: Fenway Park in Boston, MA

TV: NESN

Odds/Point Spread: St. Louis (-152) Boston (+126)

The St. Louis Cardinals (4-2) are on their way to Fenway Park on Sunday where they will try to beat the Boston Red Sox (3-4). The odds on this game have the Cardinals at -152 while the Red Sox are at +126. The total has been set at 9. The pitchers taking the mound are Miles Mikolas and Sean Newcomb.

St. Louis is slugging .498 and have been called out on strikes 46 times, while drawing a walk on 28 occasions. They have tallied 40 runs batted in as well as 64 base knocks this season, while their team batting average is at .298. The Cardinals have tallied 10 two-baggers as a unit and have hit 11 baseballs out of the stadium. They have 42 runs and hold an on-base percentage of .381. As a team, the St. Louis Cardinals are scoring 7.0 runs per contest, which has them sitting at 2nd in MLB.

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The Cardinals are sitting with a team ERA of 3.47 this season (13th in MLB), and their staff has struck out 46 hitters. Cardinals pitchers have yielded 4 long balls and also 25 runs (13th in the league). They have walked 13 opposing players and their FIP is 2.94 as a unit this year. St. Louis has yielded 36 base hits (5.7 per 9 innings) in addition to 22 earned runs. They have accrued a K/BB ratio of 3.54 and their pitching staff sits with a WHIP of 0.86.

The Cardinals relief pitchers have recorded a save percentage of 66.7% and has come into the game in 10 save situations. The relief pitchers have inherited 5 runners this season and 40.0% of those players ended up crossing the plate. Cardinals relief pitchers have entered the contest with runners on 6 times and also have had 14 appearances in high leverage situations. The Cardinals have sent 21 relievers to the mound on the season. The relievers have notched 7 holds this year (7th in baseball). They have 2 saves for the year and have not converted 1 out of their 3 save opportunities.

The Cardinals have converted 78.5% of baseballs in play into outs out of their 513 innings on the diamond, which ranks them 3rd in professional baseball. The St. Louis Cardinals have a tally of 171 putouts on the campaign, in addition to 68 assists and 1 error. Their fielding percentage is holding at .996 which has them sitting 3rd in pro baseball, and have earned 5 double plays.

Mikolas (64-64 career record) has a FIP of 4.09 and he has gone up against 4,569 hitters during his time in the majors. He has given up 1,110 hits (9.1 hits per nine innings) and has 211 free passes. His ERA is 4.15 (508 earned runs allowed) and he has a WHIP of 1.200. Mikolas has taken the mound for 1,101 innings and is sitting with 798 K's so far in his pro baseball career.

The Red Sox have a slugging percentage of .371 and they are recording 3.86 runs per outing (15th in baseball). They have hit 11 doubles, while taking a walk 25 times as well as earning 27 runs. Boston has knocked in 7 home runs on the year and 26 RBIs. They have been rung up on 75 instances (2nd in baseball) and have accounted for 55 base knocks. The Boston Red Sox have a team OBP of .303 in addition to a batting average of .229 for the season.

The Boston pitching staff have conceded 25 runs this season while having an ERA of 3.81 (25 earned runs relinquished). They have allowed 6 long balls and they surrender 3.81 runs per 9 innings (11th in MLB). The Red Sox hold a team WHIP of 1.186 and are the owners of a FIP of 3.44 as a squad on the year. Their strikeout to walk ratio comes in at 7.20 (47 strikeouts against 14 walks). They are sitting at 21st in baseball as a staff in total hits surrendered with 56.

With 3 save situations, the Red Sox have amassed 1 hold in addition to 0 blown saves. Boston has called on relief pitchers to step onto the hill in 2 save chances and they have earned 2 saves. Their relievers have come in 2 times in high leverage situations in addition to 4 occasions with runners on base. Boston relievers hold an inherited score rate of 57.1% out of their 7 inherited runners. They are ranked 2nd in baseball with a save rate of 100.0%, and they have dispatched 19 relievers onto the field on the campaign.

The Boston Red Sox have gotten 11 double plays and have earned a fielding percentage of .988 (12th in the majors). The Red Sox have 63 assists, 3 errors and have accounted for 177 putouts this season. In their 531 innings played, the Red Sox are sitting with a defensive efficiency of 69.0% (22nd in pro baseball).

Newcomb (28-26 career record) has a 4.55 earned run average while surrendering 8.4 hits per nine innings. He has a strikeout to walk ratio of 1.86 and he has gone up against 1,923 batters during his career. He has given up a total of 220 ER's while earning a WHIP of 1.476 and having a FIP of 4.5. During his MLB career, Newcomb has conceded 404 hits while totaling 442 K's in 435 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (-152)

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