San Diego Padres vs Detroit Tigers Prediction, 4/21/2025 MLB Picks, Best Bets & Odds
Game: San Diego Padres vs Detroit Tigers
Date: Monday, April 21, 2025
Location: Comerica Park in Detroit, MI
TV: FanDuel Sports Network Detroit
Odds/Point Spread: San Diego (-160) Detroit (+132)
The Detroit Tigers (11-8) will play the San Diego Padres (15-4) at Comerica Park on Monday. The moneyline on this game has the Padres at -160 while the Tigers are sitting at +132. The betting total is set at 8. The starting pitchers are Randy Vasquez and Jack Flaherty.


As a team, the San Diego Padres are notching 4.6 runs per outing, which has them sitting at 10th in the league. They have racked up 88 runs while holding a team OBP of .348. The Padres have recorded 32 doubles as a team and have hit 19 baseballs out of the park. They have earned 80 runs batted in in addition to 171 hits this year, while their batting average comes in at .274. San Diego has a slugging rate of .417 and have been called out on strikes 124 times, while being walked on 70 occasions.
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The Padres have a team ERA of 2.56 this season (2nd in the league), and the staff has struck out 165 batters. Padres pitchers have conceded 13 home runs in addition to 51 runs in total (1st in MLB). They have walked 64 opposing batters and their FIP is 3.25 as a unit so far this year. San Diego has surrendered 117 base knocks (6.2 per 9 innings) and 48 earned runs. Their strikeout to walk ratio is 2.58 and the pitching staff holds a collective WHIP of 1.07.
Padres bullpen pitchers have come into the game with opponents on base 15 times and also have had 29 appearances in high leverage situations. The bullpen have a total of 17 holds for the season (4th in the league). The Padres relievers have a save percentage of 90.0% and have come into the game in 27 save situations. They have tallied 9 saves this season and have blown 1 of their 10 chances to save the game. The bullpen pitchers have inherited 22 base runners for the year and 27.3% of them earned a run for their team. The Padres have dispatched 65 relief pitchers to the mound for the year.
The San Diego Padres have earned a total of 507 putouts over the course of the season, in addition to 140 assists and 9 errors. Their fielding rate is holding at .986 which has them sitting 14th in professional baseball, and have a total of 14 double plays. The Padres have converted 74.7% of balls hit into play into outs in their 1,521 innings on the field, which has them sitting 2nd in baseball.
Vasquez has taken the mound for 155 innings and is sitting with 103 K's during his pro baseball career. Vasquez (7-10 career record) has earned a FIP of 3.94 while he has faced 683 hitters during his time in the majors. His earned run average is 4.00 (69 earned runs allowed) and he has a WHIP of 1.441. He has allowed 163 base knocks (9.4 hits per 9 innings) and has 61 walks.
Detroit has a total of 20 HRs on the campaign as well as 84 runs batted in. They have 26 two-baggers, while walking 71 times as well as scoring 87 runs. The Detroit Tigers have tallied an on-base percentage of .322 and a team batting average of .243 this season. The Tigers have a team slugging % of .393 and they tally 4.58 runs per game (11th in the league). They have been rung up on 182 instances (4th in MLB) and have earned 155 base knocks.
The Tigers are sitting with a team WHIP of 1.133 in addition to having a FIP of 4.02 as a pitching staff on the season. They are currently ranked 5th in the league as a staff in total hits conceded with 130. The Detroit pitching staff have allowed 68 runs for the season while having a team ERA of 3.38 (62 earned runs relinquished). Their K/BB ratio sits at 8.20 (151 strikeouts vs 57 free passes). They have conceded 21 HR's and they relinquish 3.71 runs per 9 innings (3rd in baseball).
Detroit relief pitchers have an inherited score rate of 20.0% out of their 20 inherited runners. Their bullpen pitchers have stepped onto the hill 8 times in high leverage situations in addition to 16 occasions with runners on base. Sitting with 10 save situations, the Tigers have 3 holds and 1 blown save. They are ranked 5th in the league with a save percentage of 83.3%, and they have dispatched 51 bullpen pitchers to the mound for the year. Detroit has had relief pitchers step onto the hill in 6 save opportunities and they have tallied 5 saves.
The Detroit Tigers have turned 11 double plays and have a fielding rate of .989 (5th in professional baseball). The Tigers have recorded 157 assists, 7 errors and have amassed 496 putouts this season. In 1,488 innings on the diamond, the Tigers hold a efficiency on defense of 74.4% (3rd in pro baseball).
During his MLB career, Flaherty has surrendered 703 hits and he has 967 K's in 850 innings. Flaherty (56-42 win-loss record in his career) has a 3.61 earned run average while allowing 7.4 hits per nine innings. He has allowed a total of 341 ER's while holding a WHIP of 1.181 and having a FIP of 3.6. His K/BB ratio is 3.21 and he has faced 3,526 hitters during his MLB career.
Who will win tonight's MLB game against the spread or moneyline?
Guy Bruhn's Pick: Take Detroit (+132)
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Additional Resources:
Detroit Tigers - Twitter
San Diego Padres - Twitter