San Diego Padres vs Chicago Cubs Prediction, 4/6/2025 MLB Picks, Best Bets & Odds
Game: San Diego Padres vs Chicago Cubs
Date: Sunday, April 6, 2025
Location: Wrigley Field in Chicago, IL
TV: Marquee
Odds/Point Spread: San Diego (-150) Chicago (+125)
The Chicago Cubs (5-4) welcome the San Diego Padres (7-0) at Wrigley Field on Sunday. The moneyline on this matchup has San Diego at -150 and Chicago is opening at +125. The total comes in at 9. The starting pitchers are Kyle Hart and Ben Brown.


The Padres have accrued 13 two-baggers as a squad and have hit 6 baseballs out of the stadium. San Diego is slugging .440 and have been called out on strikes 40 times, while being walked on 26 occasions. As a squad, the San Diego Padres are earning 5.1 runs per game, which has them sitting at 8th in baseball. They have amassed 33 runs batted in and 65 base knocks on the season, and their average at the plate is at .298. They have tallied 36 runs while holding a team OBP of .369.
Get all of our MLB Parlay Picks
The Padres are sitting with a team earned run average of 1.57 on the campaign (1st in baseball), and their staff has rung up 69 batters. Padres pitchers have allowed 5 long balls and also 11 runs in total (1st in MLB). Their pitching staff has walked 21 opposing hitters and their FIP sits at 2.84 as a squad so far this season. San Diego has conceded 36 base hits (5.1 per 9 innings) and 11 earned runs. They have earned a K/BB ratio of 3.29 and the pitching staff holds a WHIP of 0.90.
Padres pitchers have stepped onto the hill with opponents on base 6 times as well as having 8 appearances in high leverage situations. The relievers have 6 holds for the year (9th in the league). The Padres relievers have accumulated a save rate of 100.0% and stepped onto the hill in 10 save situations. They have compiled 4 saves on the season and have blown 0 of their 4 chances to get a save. The relief pitchers have inherited 9 base runners this year with 0.0% of those runners crossed the plate. The Padres have sent 26 relief pitchers to the hill for the season.
The Padres have turned 77.7% of balls hit into play into outs out of 567 innings on the field, which has them sitting at 4th in MLB. The San Diego Padres have a tally of 189 putouts at this point in the season, as well as 52 assists and 2 errors. Their fielding rate is holding steady at .992 which has them sitting 8th in the majors, and they have turned 6 double plays.
Hart has pitched in 16 innings and has accumulated 17 strikeouts during his career. His ERA is 11.81 (21 ER's allowed) and his career WHIP is 2.500. He has conceded 29 base knocks (16.3 hits per 9 innings) and has 11 walks. Hart (1-1 win-loss record in his career) has a FIP of 11.64 and he has gone up against 86 batters in the majors.
The Chicago Cubs have accumulated an on-base percentage of .344 in addition to a team batting average of .255 on the season. They have been called out on strikes on 79 occasions (1st in the league) and have tallied 84 base hits. Chicago has hit 14 HRs over the course of the season and 60 RBIs. The Cubs hold a slugging percentage of .450 and they are recording 6.67 runs per contest (3rd in the league). They have recorded 20 doubles, while getting a free base 43 times as well as notching 60 runs.
The Chicago pitching staff have allowed 46 runs for the season while holding a team ERA of 5.13 (45 earned runs surrendered). They have conceded 12 long balls and they concede 5.24 runs per 9 innings (22nd in baseball). The Cubs have a team WHIP of 1.544 and are the owners of a FIP of 4.85 as a team on the season. Their K/BB ratio sits at 7.10 (62 strikeouts against 39 walks). They rank 30th in MLB as a pitching staff in total hits conceded with 83.
Chicago has called on relievers to take the mound in 4 save chances and they have tallied 3 saves. They rank 13th in the league with a save rate of 75.0%, and they have sent 28 bullpen pitchers to the hill for the season. Their bullpen pitchers have stepped onto the hill 2 times in high leverage situations and on 5 occasions with runners on. Chicago bullpen pitchers hold an inherited score percentage of 57.1% of 7 inherited base runners. With 11 save situations, the Cubs have earned 7 holds and 1 blown save.
In their 711 innings played, the Cubs have a defensive efficiency of 68.8% (24th in professional baseball). The Chicago Cubs have gotten 10 double plays and have accounted for a fielding rate of .988 (13th in professional baseball). The Cubs have 82 assists, 4 errors and have notched a total of 237 putouts for the season.
So far in his pro baseball career, Brown has surrendered 51 hits and he has 74 punch outs in 62 innings. Brown (2-4 mark in his career) has a 3.90 ERA and has allowed 7.4 hits per nine innings. He has given up a total of 27 ER's while holding a WHIP of 1.204 and having a FIP of 3.8. He has a K/BB ratio of 3.08 and he has gone up against 260 hitters so far in his career.
Who will win tonight's MLB game against the spread or moneyline?
Parlay's Pundit's Pick: Take Chicago (+125) and under 9 runs
Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here
Get all of Today's Free MLB Picks
Get all of Today's Expert MLB Picks
Additional Resources:
Chicago Cubs - Twitter
San Diego Padres - Twitter