Los Angeles Dodgers vs Chicago Cubs Prediction, 4/22/2025 MLB Picks, Best Bets & Odds

Game: Los Angeles Dodgers vs Chicago Cubs

Date: Tuesday, April 22, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Los Angeles (-122) Chicago (+102)

Wrigley Field is where the Chicago Cubs (14-10) will go up against the Los Angeles Dodgers (16-7) on Tuesday. The moneyline on this game has the Dodgers at -122 while the Cubs are coming in at +102. The betting total is set at 9. The men taking the mound will be Dustin May and Shota Imanaga.

As a squad, the Los Angeles Dodgers are compiling 4.4 runs per contest, which ranks them 15th in MLB. They have accumulated 100 runs while having a team OBP of .311. The Dodgers have accounted for 27 doubles as a squad and have hit 36 baseballs out of the park. They have 97 runs batted in in addition to 168 hits so far this season, while their average at the plate sits at .227. Los Angeles is slugging .415 and have struck out 192 times, while drawing a walk on 82 occasions.

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They have earned a strikeout to walk ratio of 2.52 and their pitching staff has earned a collective WHIP of 1.24. Dodgers pitchers have given up 21 long balls in addition to 90 total runs (12th in MLB). Los Angeles has surrendered 163 base hits (7.2 per 9 innings) as well as 80 earned runs. The Dodgers hold a team earned run average of 3.55 on the season (7th in MLB), and the staff has struck out 222 batters. Their pitching staff has walked 88 players from the other team and their FIP comes in at 3.57 as a squad so far this year.

The Dodgers bullpen have compiled a save rate of 78.6% and have entered the game in 42 save situations. The bullpen pitchers have inherited 18 runners over the course of the season with 22.2% of those players ended up crossing the plate. Dodgers bullpen pitchers have entered the game with runners on 13 times as well as having 29 appearances in high leverage situations. The Dodgers have sent 88 relievers to the hill this year. The relief pitchers have notched 26 holds so far this season (1st in the league). They have compiled 11 saves on the year and have blown 3 of 14 chances to get a save.

The Dodgers have transformed 71.1% of balls hit into play into outs out of their 1,827 innings, ranking them 15th in MLB. The Los Angeles Angels have earned 609 putouts for the season, in addition to 186 assists and 9 errors. Their fielding percentage is at .989 which is 6th in MLB, and they have turned 14 double plays.

May (13-10 career record) holds a FIP of 2.90 while going up against 837 batters in the majors. He has conceded 151 hits (6.5 hits per 9 innings) and has had 63 walks. His ERA is 2.94 (68 earned runs allowed) and he has a career WHIP of 1.028. May has taken the hill for 208 innings and has accumulated 188 K's so far in his career.

The Cubs hold a team SLG% of .447 and they are scoring 6.04 runs per outing (1st in the league). They have recorded 44 two-baggers, while getting a free base 97 times and scoring 145 runs. Chicago has hit 34 home runs for the season as well as 142 RBIs. They have been rung up on 197 occasions (10th in MLB) and have earned 218 base knocks. The Chicago Cubs have tallied a team on-base percentage of .338 in addition to a batting average of .258 on the season.

The Cubs hold a team WHIP of 1.369 and are the owners of a FIP of 4.23 as a unit so far this year. They are sitting at 29th in baseball as a pitching staff in total hits allowed with 206. The Chicago pitching staff have allowed 104 runs for the season while holding a team ERA of 4.16 (99 earned runs yielded). They currently have a K/BB ratio of 7.90 (188 strikeouts vs 87 free passes). They have given up 27 long balls and they give up 4.37 runs per 9 innings (14th in MLB).

Sitting with 27 save situations, the Cubs have earned 15 holds in addition to 5 blown saves. Chicago has had bullpen pitchers step onto the mound in 11 save opportunities and they have come away with 6 saves. Their relief pitchers have stepped onto the mound 26 times in high leverage situations and also on 19 occasions with runners on. Chicago relievers have an inherited score rate of 39.3% out of 28 inherited base runners. They are ranked 24th in baseball with a save rate of 54.5%, and they have sent 83 relief pitchers to the hill on the year.

In their 1,926 innings on the diamond, the Cubs hold a efficiency on defense of 69.6% (20th in professional baseball). The Chicago Cubs have turned 14 double plays and have a fielding percentage of .984 (21st in baseball). The Cubs have racked up 193 assists, 14 errors and have a tally of 642 putouts over the course of the season.

Imanaga (17-4 win-loss mark in his career) has earned a 2.82 ERA and has given up 7.5 hits per nine innings. His K/BB ratio is 5.13 and he has faced 807 opposing hitters during his MLB career. He has given up 63 earned runs while earning a WHIP of 1.019 and being the owner of a FIP of 2.8. In his career, Imanaga has given up 167 hits and he has 195 K's in 201 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Los Angeles (-122)

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