Cleveland Guardians vs Los Angeles Angels Prediction, 4/6/2025 MLB Picks, Best Bets & Odds
Game: Cleveland Guardians vs Los Angeles Angels
Date: Sunday, April 6, 2025
Location: Angel Stadium in Anaheim, CA
TV: FanDuel Sports Network West
Odds/Point Spread: Cleveland (+162) Los Angeles (-196)
The Los Angeles Angels (4-2) will take on the Cleveland Guardians (2-4) at Angel Stadium on Sunday. The odds on this game have Cleveland at +162 and Los Angeles is at -196. The over/under is 8.5. The starting pitchers will be Luis Ortiz and Tyler Anderson.


The Guardians have accrued 9 doubles as a squad and have hit 7 baseballs out of the park. Cleveland has a slugging rate of .392 and have struck out 49 times, while drawing a walk on 18 occasions. As a squad, the Cleveland Guardians are compiling 3.3 runs per outing, which has them sitting at 22nd in the league. They have amassed 20 runs batted in and 44 base knocks on the year, while their batting average comes in at .227. They have accounted for 20 runs and have an on-base percentage of .295.
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The Guardians have an ERA of 4.41 this season (18th in the league), and their staff has rung up 32 batters. Guardians pitchers have conceded 5 home runs and 29 runs (15th in baseball). Their pitching staff has walked 21 players from the other team and their FIP sits at 4.22 as a team on the campaign. Cleveland has surrendered 54 base hits (9.5 per 9 innings) in addition to 25 earned runs. They have accumulated a K/BB ratio of 1.52 and their pitching staff holds a collective WHIP of 1.47.
The Guardians have sent 21 relievers to the mound on the year. The relief pitchers have inherited 11 base runners on the season and 36.4% of them earned a run for their team. They have compiled 1 save this year and have missed out on 2 of their 3 save chances. The Guardians relievers have recorded a save rate of 33.3% and has stepped onto the mound in 8 save situations. The relief pitchers have 5 holds this season (11th in the league). Guardians relief pitchers have entered the game with players on base 8 times as well as having 9 appearances in high leverage situations.
The Cincinnati Reds have a total of 153 putouts thus far, as well as 49 assists and 5 errors. Their fielding percentage is holding at .976 which ranks 28th in pro baseball, and have 7 double plays. The Guardians have turned 67.9% of balls hit into play into outs out of 459 innings on the field, which has them sitting 25th in pro baseball.
Ortiz has thrown 242 innings and has racked up 185 strikeouts so far in his career. His earned run average is 4.12 (111 earned runs allowed) and he has a WHIP of 1.358. He has given up 225 hits (8.4 hits per nine innings) and has had 104 free passes. Ortiz (12-14 career win-loss mark) is the owner of a FIP of 4.06 while facing 1,051 hitters during his time in the major leagues.
The Angels have a slugging percentage of .310 and they are recording 4.00 runs per contest (14th in MLB). They have put up 6 doubles, while taking a walk 16 times and earning 24 runs. Los Angeles has tallied 4 long balls on the campaign and 24 runs batted in. They have been rung up on 50 instances (20th in the league) and have 39 hits. The Los Angeles Angels have a team on-base percentage of .267 and a batting average of .198 over the course of the season.
The Angels are sitting with a team WHIP of 1.382 and are the owners of a FIP of 4.85 as a unit this year. Their strikeout to walk ratio sits at 7.50 (46 strikeouts against 24 bases on balls). They come in at 16th in the league as a pitching staff in total hits given up with 52. They have allowed 10 home runs and they relinquish 5.40 runs per 9 innings (25th in the league). The Los Angeles pitching staff have given up 33 runs for the season while having an ERA of 4.58 (28 earned runs relinquished).
With 11 save situations, the Angels have earned 4 holds in addition to 3 blown saves. Los Angeles has had relief pitchers step onto the mound in 7 save opportunities and they have come away with 4 saves. Their relievers have stepped onto the hill 17 times in high leverage situations in addition to 7 occasions with base runners. Los Angeles relievers hold an inherited score rate of 44.4% out of 9 inherited base runners. They rank 17th in MLB with a save rate of 57.1%, and they have sent 22 relievers onto the diamond so far this year.
In 495 innings on the diamond, the Angels are sitting with a defensive efficiency of 72.0% (14th in professional baseball). The Los Angeles Angels have turned 6 double plays and own a fielding percentage of .991 (11th in pro baseball). The Angels have 55 assists, 2 errors and are sitting with 165 putouts this year.
So far in his MLB career, Anderson has allowed 1,088 hits while earning 945 K's in 1,127 innings pitched. Anderson (60-64 career mark) is the owner of a 4.27 ERA while giving up 8.7 hits per 9 innings. He has given up a total of 535 earned runs while holding a WHIP of 1.285 and a FIP of 4.2. He has a strikeout to walk ratio of 2.63 and he has faced 4,769 batters during his career.
Who will win tonight's MLB game against the spread or moneyline?
Tony Sink's Pick: Take Cleveland (+162)
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Additional Resources:
Los Angeles Angels - Twitter
Cleveland Guardians - Twitter