Chicago White Sox vs Boston Red Sox Prediction, 4/21/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Boston Red Sox

Date: Monday, April 21, 2025

Location: Fenway Park in Boston, MA

TV: NESN

Odds/Point Spread: Chicago (+110) Boston (-132)

The Boston Red Sox (10-10) will play the Chicago White Sox (4-14) at Fenway Park on Monday. The moneyline on this contest has Chicago at +110 and Boston is at -132. The over/under is 8.5. The pitchers who are expected to start are Jonathan Cannon and Walker Buehler.

The White Sox have tallied 19 doubles as a unit and have smacked 12 baseballs out of the park. Chicago has a slugging % of .296 and have struck out 150 times, while drawing a walk on 58 occasions. As a team, the Chicago White Sox are putting up 3.0 runs per game, which has them at 28th in MLB. They have 52 runs batted in as well as 112 hits on the season, while their average at the plate is at .196. They are sitting with 54 runs while holding a team on-base percentage of .270.

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The White Sox hold a team ERA of 4.26 on the season (22nd in the league), and the staff has struck out 136 batters. White Sox pitchers have conceded 21 long balls in addition to 76 total runs (10th in MLB). Their pitching staff has walked 67 opposing batters and their FIP is 4.52 as a team on the season. Chicago has yielded 139 hits (8.0 per 9 innings) and 74 earned runs. They have earned a K/BB ratio of 2.03 and their pitching staff sits with a WHIP of 1.32.

The White Sox have sent 59 relief pitchers to the hill on the season. The bullpen pitchers have inherited 26 runners so far this year and 38.5% of them ended up scoring. They have earned no saves on the campaign and have missed out on both of their save opportunities. The White Sox bullpen have a save rate of 0.0% and stepped onto the hill in 9 save situations. The relievers have tallied 7 holds so far this year (26th in MLB). White Sox pitchers have come into the game with runners on base 16 times and also have had 13 appearances in high leverage situations.

The Chicago Cubs have a tally of 469 putouts on the campaign, as well as 157 assists and 11 errors. Their fielding rate is at .983 which is 22nd in baseball, and have a total of 15 double plays. The White Sox have turned 71.4% of balls hit into play into outs in their 1,407 innings, which has them sitting at 11th in professional baseball.

Cannon has pitched in 142 innings and has tallied 109 K's so far in his MLB career. Cannon (5-12 career win-loss record) sits with a FIP of 4.43 and he has faced 606 hitters during his time in the major leagues. His earned run average is 4.49 (71 ER's allowed) and he has a WHIP of 1.357. He has allowed 142 hits (9.0 hits per 9 innings) with 51 walks.

Boston has a total of 17 home runs for the year as well as 82 RBIs. They have 38 two-baggers, while taking a walk 71 times as well as putting up 86 runs. The Boston Red Sox are sitting with an OBP of .320 and a batting average of .247 for the year. The Red Sox have a team SLG% of .382 and they score 4.30 runs per contest (14th in baseball). They have struck out on 197 instances (1st in MLB) and have earned 171 base knocks.

The Boston pitching staff have allowed 97 runs this season while holding an ERA of 4.17 (82 earned runs yielded). They have allowed 16 long balls and they relinquish 4.93 runs per 9 innings (25th in the league). The Red Sox hold a team WHIP of 1.327 with a FIP of 3.41 as a squad on the year. Their strikeout to walk ratio is 8.40 (166 strikeouts vs 58 free passes). They are currently ranked 29th in the league as a pitching staff in total hits given up with 177.

Boston has called on relievers to enter the game in 10 save opportunities and they have tallied 7 saves. They rank 9th in the league holding a save percentage of 70.0%, and they have sent 62 relievers onto the diamond on the season. Their relief pitchers have stepped onto the mound 21 times in high leverage situations and on 18 occasions with runners on. Boston relief pitchers have an inherited score percentage of 50.0% out of 24 inherited runners. With 15 save situations, the Red Sox have tallied 5 holds and also 3 blown saves.

Out of their 1,596 innings played, the Red Sox have accumulated a defensive efficiency of 65.7% (30th in baseball). The Boston Red Sox have turned 23 double plays and hold a fielding percentage of .973 (30th in professional baseball). The Red Sox have recorded 183 assists, 20 errors and have accumulated 532 putouts this year.

Thus far in his career, Buehler has surrendered 609 hits while he has accumulated 771 punch outs in 733 innings pitched. Buehler (49-23 career record) has earned a 3.33 ERA while giving up 7.5 hits per nine innings. He has surrendered 271 earned runs while earning a WHIP of 1.096 and being the owner of a FIP of 3.3. His strikeout to walk ratio is 3.95 and he has faced 2,990 batters in his career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (+110)

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