Chicago Cubs vs San Diego Padres Prediction, 4/16/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs San Diego Padres

Date: Wednesday, April 16, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Chicago (+132) San Diego (-160)

The Chicago Cubs (11-8) are en route to Petco Park on Wednesday where they will go up against the San Diego Padres (14-3). The moneyline on this matchup has Chicago at +132 and San Diego is coming in at -160. The over/under comes in at 9. The pitchers taking the mound are Matthew Boyd and Nick Pivetta.

Chicago has a slugging percentage of .441 and have struck out 154 times, while drawing a walk on 86 occasions. They have 117 runs batted in and 172 base knocks on the season, while their average at the plate comes in at .258. The Cubs have accrued 36 two-baggers as a squad and have smacked 26 baseballs out of the stadium. They have earned 120 runs scored while holding a team on-base percentage of .347. As a team, the Chicago Cubs are recording 6.3 runs per game, which puts them at 1st in the league.

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The Cubs have compiled a team earned run average of 4.37 over the course of the season (20th in MLB), and their staff has rung up 143 batters. Cubs pitchers have allowed 22 home runs and 83 total runs (25th in the league). Their pitching staff has walked 66 opposing players and their FIP sits at 4.32 as a squad for the year. Chicago has given up 166 base knocks (8.9 per 9 innings) and also 81 earned runs. Their strikeout to walk ratio is 2.17 and their pitching staff holds a collective WHIP of 1.39.

Cubs relief pitchers have stepped onto the hill with players on base 12 times as well as having 14 appearances in high leverage situations. The bullpen have 13 holds on the season (8th in the league). The Cubs relief pitchers have a save percentage of 50.0% and has come into the game in 23 save situations. They have compiled 5 saves so far this year and have blown 5 out of their 10 chances to get a save. The bullpen pitchers have inherited 16 base runners for the season and 37.5% of those players crossed home plate. The Cubs have dispatched 60 relievers to the hill for the season.

The Cubs have converted 69.5% of balls hit into play into outs out of their 1,503 innings on the diamond, ranking them 21st in baseball. The Boston Red Sox have earned 501 putouts so far this season, in addition to 156 assists and 7 errors. Their fielding rate is holding steady at .989 which is 6th in MLB, and have 13 double plays.

Boyd has thrown 925 innings and has racked up 908 K's in his MLB career. Boyd (47-70 career win-loss record) is the owner of a FIP of 4.71 while he has gone up against 3,967 batters during his time in the majors. His ERA is 4.79 (492 earned runs allowed) and he has a WHIP of 1.311. He has conceded 912 base knocks (8.9 hits per 9 innings) with 301 walks.

The San Diego Padres have accumulated an on-base percentage of .352 and a batting average of .284 so far this year. They have struck out on 109 occasions (29th in MLB) and have totaled 159 hits. San Diego has knocked in 18 home runs for the year and 75 runs batted in. The Padres have a team SLG% of .433 and they average 4.88 runs per outing (8th in baseball). They have recorded 29 doubles, while getting a free base 59 times as well as notching 83 runs.

The Padres have a team WHIP of 1.073 in addition to having a FIP of 3.38 as a team for the season. They have earned a strikeout to walk ratio of 8.90 (148 strikeouts vs 60 walks). They are currently ranked 2nd in MLB as a staff in total hits given up with 101. They have given up 12 homers and they surrender 2.82 runs per 9 innings (2nd in the league). The San Diego pitching staff have surrendered 47 runs this year while having a team ERA of 2.70 (45 earned runs relinquished).

San Diego relievers hold an inherited score percentage of 26.3% of 19 inherited runners. Their bullpen pitchers have come in 22 times in high leverage situations and also on 12 occasions with runners on. With 23 save situations, the Padres have 15 holds and also no blown saves. They sit at 3rd in baseball with a save percentage of 100.0%, and they have sent 57 relief pitchers to the mound over the course of the season. San Diego has called on bullpen pitchers to step onto the mound in 8 save opportunities and they have earned 8 saves.

The San Diego Padres have turned 13 double plays and own a fielding percentage of .986 (10th in MLB). The Padres have accrued 126 assists, 8 errors and have 450 putouts for the year. In 1,350 innings on the diamond, the Padres have accumulated a defensive efficiency of 75.2% (2nd in pro baseball).

In his pro baseball career, Pivetta has surrendered 988 hits while earning 1,157 K's in 1,046 innings. He has conceded a total of 547 ER's while earning a WHIP of 1.309 and a FIP of 4.6. His K/BB ratio is 3.04 and he has gone up against 4,451 batters thus far in his career. Pivetta (58-72 record in his career) has a 4.71 ERA and has surrendered 8.5 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (+132)

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