St. Louis Cardinals vs Chicago Cubs Prediction, 9/25/2021 MLB Pick, Tips and Odds

Game: St. Louis Cardinals vs Chicago Cubs

Date: Saturday, September 25, 2021

Location: Wrigley Field in Chicago, IL

TV: Marquee Sports Network

Odds/Point Spread: St. Louis (-150) Chicago (+126)

Wrigley Field is the venue where Adrian Sampson and the Chicago Cubs (67-85, 4th in NL Central) will take on the St. Louis Cardinals (83-69, 2nd in NL Central) on Saturday. The Cubs open this matchup at +126 while the Cardinals are coming in at -150. The total opens at 8.5. The starting pitchers will be Jon Lester and Adrian Sampson.

As a unit, the St. Louis Cardinals are notching 4.3 runs/g, which has them at 22nd in the league. They have accumulated 645 runs scored while holding a team on-base percentage of .311. The Cardinals have recorded 248 doubles as a squad and have knocked 174 balls out of the park. They have amassed 623 runs batted in and 1,210 base knocks on the season, while their batting average is sitting at .242. St. Louis is slugging .404 and have been rung up 1,256 times, while taking a walk on 445 occasions.

Get all of our MLB Picks

The Cardinals hold a team earned run average of 3.98 over the course of the season (14th in baseball), and their staff has rung up 1,134 batters. Their K/BB ratio is 2.00 and their pitching staff has recorded a WHIP of 1.29. Cardinals pitchers have relinquished 140 home runs in addition to 630 total runs (9th in baseball). Their pitching staff has walked 567 opposing batters and their FIP is 4.29 as a team over the course of the season.

The Cardinals relievers have accumulated a save rate of 70.8% and has entered the game in 168 save situations. The relief pitchers have inherited 262 runners over the course of the season and 37.0% of those players crossed home plate. Cardinals pitchers have come into the game with players on base 159 times as well as having 152 appearances in high leverage situations. The Cardinals have sent 520 relief pitchers to the mound so far this year. The relief pitchers have racked up 101 holds on the year (4th in the league). They have earned 46 saves on the campaign and have blown 19 of 65 chances to get a save.

The Cardinals have transformed 71.6% of balls in play into outs out of 11,916 innings, ranking them 2nd in the majors. The St. Louis Cardinals are sitting with 3,972 putouts for the season, in addition to 1,406 assists and 82 errors. Their fielding rate is at .985 which is 15th in professional baseball, and have accumulated 1,070 double plays.

Lester has thrown 2,730 frames and has tallied 2,478 strikeouts so far in his career. His ERA is 3.65 (1,107 ER's allowed) and his WHIP is 1.275. He has given up 2,596 base hits (8.6 hits per 9 innings) with 885 free passes. Lester (200-117 mark in his career) sits with a FIP of 3.78 while he has gone up against 11,437 opposing hitters in the majors.

The Chicago Cubs have a team on-base percentage of .308 and a batting average of .234 on the season. They have struck out on 1,520 instances (1st in MLB) and have a total of 1,165 base hits. Chicago has hit 202 home runs on the campaign and 627 RBIs. The Cubs hold a team slugging percentage of .406 and they are scoring 4.34 runs per contest (20th in baseball). They have recorded 204 two-baggers, while walking 457 times and putting up 659 runs.

The Cubs hold a team WHIP of 1.402 and have a FIP of 4.84 as a pitching staff so far this season. Their strikeout to walk ratio is 2.27 (1,282 strikeouts against 565 bases on balls). They come in at 25th in the league as a staff in total hits relinquished with 1,300. They have surrendered 217 HR's and they allow 5.32 runs per 9 innings (27th in MLB). The Chicago pitching staff have conceded 786 runs over the course of the season while holding an ERA of 4.85 (716 earned runs surrendered).

With 125 save situations, the Cubs have compiled 72 holds in addition to 14 blown saves. Chicago has had relief pitchers take the mound in 52 save chances and they have come away with 38 saves. Their relief pitchers have taken the field 161 times in high leverage situations in addition to 162 occasions with runners on base. Chicago relievers hold an inherited score percentage of 35.2% out of their 267 inherited base runners. They are ranked 1st in MLB with a save rate of 73.1%, and they have sent 565 relievers to the hill so far this year.

The Chicago Cubs have turned 135 double plays and own a fielding percentage of .985 (14th in the majors). The Cubs have accrued 1,461 assists, 83 errors and have earned 3,990 putouts this season. In 11,970 innings played, the Cubs have accumulated a defensive efficiency of 69.1% (21st in baseball).

Sampson (7-14 career record) has earned a 5.30 ERA while surrendering 10.7 hits per 9 innings. His K/BB ratio is 2.87 and he has faced 786 batters in his career. He has conceded 105 earned runs while earning a WHIP of 1.452 and a FIP of 5.8. During his MLB career, Sampson has surrendered 212 hits while he has earned 135 K's in 178 innings.

Who will win tonight's baseball game against the spread?

Tony Sink's Pick: Take Chicago (+126)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here